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KMID : 0368820040430010023
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Journal of the Korean Neuropsychiatr Association
2004 Volume.43 No. 1 p.23 ~ p.27
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Schizophrenia and Glutathione S-transferase P Gene Polymorphism
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Abstract
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Objectives : This study is aimed to test the association between the coding sequence functional polymorphism (1105 V) of glutathione S-transferase P gene (GSTP1) and schizophrenia.
Methods : Two hundred fourteen (214) patients with schizophrenia according to the DSM-IV criteria and one hundred ten (110) healthy controls were enrolled in this study. Patients and controls were biologically unrelated age and sex- matched native Koreans. Genotyping for the GSTP1 polymorphism was performed by polyrnerase chain reaction-restriction fragment length polymorphism.
Results : Genotype and allele distributions of the GSTPI polymorphism in patients with schizophrenia were not significantly different from those of the controls. Comparisons of clinical variables also were not different according to genotype and allele distribution.
Conclusion : The present study suggests that the GSTPI polymorphism may not confer susceptibility to development of schizophrenia, at least in the Korean population. (J Korean Neuropsychiatr Assoc 2004;43 (1) :23-28)
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